Pressure injuries are localized injuries to the skin or underlying tissue due to unrelieved pressure. This puts patients with immobility issues at greatest risk of developing pressure injuries. Other health problems, such as low immunity or advanced age, can also dramatically increase their risk. Yet even under such challenging conditions, pressure injuries can be prevented if correct steps are taken. The single most important issue regarding pressure injuries is prevention. Once a deep pressure injury forms, it is very hard to heal.