Your kidneys remove waste products and extra water from your body. When your kidneys don't work as they should, waste products build up in your blood. The early stage of this process is called renal insufficiency. If renal insufficiency gets worse, you can develop chronic renal failure. This allows extra water, waste, and toxic substances to build up in your body. This can become life-threatening. You may need dialysis or a kidney transplant. The most serious form of renal insufficiency is end-stage renal disease.
Diabetes is the main cause of renal insufficiency. Other causes include:
- High blood pressure.
- Hardening of the arteries.
- Lupus.
- Inflammation of the blood vessels (vasculitis).
- Viral or bacterial infection.
Some over-the-counter (OTC) pain medicines can cause renal failure if you take them for a long time. These include aspirin, ibuprofen, naproxen, and other nonsteroidal anti-inflammatory drugs (NSAIDs).